ABCA1-mediated lipid efflux restrains oxidative stress and neuroinflammation after spinal cord injury - PubMed
3 days ago
- #neuroinflammation
- #ABCA1
- #lipid efflux
- ABCA1-mediated lipid efflux is crucial in controlling oxidative stress and neuroinflammation after spinal cord injury (SCI).
- Deletion of ABCA1 in specific cells leads to increased lipid accumulation, oxidative stress, and impaired recovery in SCI models.
- A small molecule, Z231, identified through screening, activates ABCA1 and improves outcomes by reducing inflammation and enhancing recovery.