Decoding neurodegeneration one cell at a time - PubMed
6 hours ago
- #selective vulnerability
- #single-cell genomics
- #neurodegeneration
- Neurodegenerative diseases involve protein misfolding and selective vulnerability of specific neuronal subtypes.
- Recent genomics technologies like single-cell transcriptomics and epigenomics are uncovering mechanisms behind selective vulnerability.
- These technologies help identify affected cell types, molecular states, and potential therapeutic targets in diseases such as Alzheimer's and Parkinson's.
- Continued development of single-cell techniques will enhance understanding of neurodegeneration and aid in therapeutic development.