Physical exercise mitigates amyloid beta-driven muscle degeneration in Alzheimer's disease - PubMed
5 hours ago
- #Exercise Therapy
- #Alzheimer's Disease
- #Muscle Degeneration
- Physical exercise, specifically high-intensity interval training (HIIT), mitigates amyloid beta (Aβ)-driven muscle degeneration in Alzheimer's disease.
- Aβ activates RAGE/NF-κB signaling in skeletal muscle, leading to inflammation, oxidative stress, and muscle weakness, as observed in both AD patients and 5 × FAD mouse models.
- HIIT reverses these pathological changes and reduces Aβ levels by inducing fibroblast growth factor 10 (FGF10), which activates the FGFR2-AKT-ADAM10 axis.
- The FGF10 pathway promotes shedding of the RAGE ectodomain, generating soluble RAGE that suppresses Aβ-mediated inflammatory and injury signaling, offering a protective mechanism.
- This research reframes Alzheimer's disease as a brain-muscle axis disorder and highlights FGF10 as a promising target for systemic therapeutic interventions.