Small extracellular vesicle-integrated by herbal hydrogels for spatiotemporal immunomodulation and neurovascular repair following traumatic brain injury - PubMed
5 hours ago
- #Traumatic brain injury
- #Neuroregeneration
- #Self-assembled hydrogel
- Engineered an injectable ESC-sEV-glycyrrhizic acid (GA) co-assembled hydrogel (EG-gel) for TBI treatment.
- EG-gel combines small extracellular vesicles (ESC-sEV) with GA nanoscaffolds for enhanced brain targeting and retention.
- Exhibits brain-compatible mechanical properties, self-healing, shear-thinning injectability, and strong tissue adhesion.
- Superior neuroprotective effects and functional recovery in a mouse TBI model compared to GA-gel alone.
- Mechanism involves GA-mediated early inflammatory suppression and sEV-driven angiogenesis and neuronal repair.
- Creates a sequential 'first anti-inflammatory, then vaso-neural regeneration' microenvironment for neuroprotection.