Red ginseng polysaccharide targets the PI3K/AKT/mTOR pathway to induce mitochondrial apoptosis in bladder cancer - PubMed
5 hours ago
- #PI3K/AKT/mTOR Pathway
- #Red Ginseng Polysaccharide
- #Bladder Cancer
- Red ginseng polysaccharide (RGP) targets the PI3K/AKT/mTOR pathway to induce mitochondrial apoptosis in bladder cancer (BLC).
- Bladder cancer is the tenth most prevalent malignancy globally, with high management costs due to prolonged treatment and invasive procedures.
- RGP significantly inhibits BLC cell proliferation and downregulates PI3K subunit expression in a dose-dependent manner.
- RGP suppresses downstream signaling pathways, including AKT/mTOR and PKCα, leading to mitochondrial dysfunction and programmed cell death.
- The study highlights RGP's preclinical potential, suggesting further clinical trials to evaluate its pharmacokinetics, safety, and efficacy for metastatic bladder cancer treatment.