STING is the scaffold protein for stress granule pre-condensation at the ER - PubMed
6 hours ago
- #STING
- #Stress Granules
- #Neurodegenerative Diseases
- STING is a scaffold protein that forms a pre-condensation complex at the ER with SG core components G3BP1 and UBAP2L.
- This complex lowers the threshold for stress granule (SG) maturation upon cellular stress, independent of STING's canonical immune functions.
- Loss of STING reduces SG formation and increases stress-induced cell death, while the ER-anchored STING CTD can reverse these effects.
- STING also promotes pathologic effects of TDP-43 mutations linked to amyotrophic lateral sclerosis (ALS).
- Findings highlight STING as a potential therapeutic target in neurodegenerative diseases involving aberrant SG assembly.