Roburic acid inhibits glucocorticoid-induced osteonecrosis of the femoral head associated osteoclast activity via targeting PTP1B - PubMed
6 hours ago
- #Roburic acid
- #PTP1B
- #osteonecrosis
- Roburic acid (RA) inhibits glucocorticoid-induced osteonecrosis of the femoral head (GIONFH) by targeting PTP1B to reduce osteoclast activity.
- PTP1B is upregulated in necrotic regions of GIONFH patients and colocalizes with osteoclast markers like CTSK.
- RA dose-dependently inhibits osteoclast formation in vitro and reduces bone erosion in a rat GIONFH model.
- Molecular docking and assays confirm PTP1B as a direct binding target of RA with high affinity.
- RA suppresses the RhoA/NF-κB/NFATc1 pathway downstream of PTP1B, reducing osteoclast hyperactivity.
- RA shows potential as a preclinical candidate for GIONFH treatment.