SPP1high fibrogenic macrophages mediate protective fibrotic remodeling and promote vascular stability in hypertension-associated aortic dissection - PubMed
5 hours ago
- #Fibrosis
- #Macrophages
- #Aortic Dissection
- SPP1high fibrogenic macrophages play a protective role in hypertension-associated aortic dissection (HTN-AD) by promoting fibrotic remodeling and vascular stability.
- Single-cell RNA sequencing identified SPP1high macrophages as key mediators between low-inflammatory macrophages and matrix-active states in diseased aortas.
- Patients with HTN-AD showed increased non-classical monocytes and higher monocytic SPP1, correlating with serum TGF-β1 levels and shorter ICU stays.
- TGF-β1 induces an SPP1-dependent fibrogenic program in macrophages while suppressing inflammatory markers.
- Myeloid Spp1 deficiency worsened aortic damage, whereas adoptive transfer of TGF-β1-conditioned SPP1high macrophages improved outcomes in a murine AD model.
- Targeting the TGF-β1-SPP1 axis may offer a therapeutic strategy for acute aortic syndromes.