Brain Morphology Mediators of the Association of Childhood Trauma With Bipolar Disorder: An International ENIGMA Bipolar Disorder Working Group Study - PubMed
4 hours ago
- #Bipolar Disorder
- #Neuroimaging
- #Childhood Trauma
- Childhood trauma severity is directly associated with a higher likelihood of bipolar disorder diagnosis.
- Brain morphology (cortical thickness, surface, and subcortical volume) mediates less than 1% of the association between childhood trauma and bipolar disorder.
- Significant mediating brain regions include smaller hippocampal volume, thinner medial orbitofrontal cortex, and thinner superior frontal gyrus cortex.
- The study involved a large international sample (2,221 healthy controls and 1,031 participants with bipolar disorder) from the ENIGMA Bipolar Disorder Working Group.