A ketogenic diet enhances aerobic exercise adaptation and promotes muscle mitochondrial remodeling in hyperglycemic male mice - PubMed
5 hours ago
- #hyperglycemia
- #ketogenic diet
- #aerobic exercise
- A ketogenic diet (KETO) restores aerobic exercise adaptation in hyperglycemic male mice by normalizing blood glucose levels.
- Hyperglycemic mice on a standard high-carbohydrate diet (CHOW) show blunted improvements in VO2peak after aerobic exercise training, while those on KETO show restored improvements.
- KETO enhances aerobic remodeling of skeletal muscle, including a more oxidative fiber-type and increased capillary density.
- KETO induces exercise-independent effects on muscle mitochondrial remodeling, increasing fatty acid oxidation and down-regulating glucose metabolism.
- The study suggests a ketogenic diet as a potential therapy to improve aerobic exercise adaptation in individuals with hyperglycemia.