Microglial cathepsin B is necessary for neuronal efferocytosis in zebrafish and mice during brain development - PubMed
5 hours ago
- #brain development
- #cathepsin B
- #microglia
- Microglial cathepsin B is essential for neuronal efferocytosis in zebrafish and mice during brain development.
- Cathepsin B is enriched in microglia in brain regions with high neuronal turnover.
- Genetic disruption of cathepsin B leads to accumulation of undigested dead cells in microglia.
- Live imaging shows fewer phagocytic events and reduced overall phagocytosis in cathepsin B-deficient models.
- Behavioral impairments were observed in both zebrafish and mouse models lacking cathepsin B.
- The study highlights the role of microglial cathepsin B in vertebrate brain development.