Proton-activated chloride channel 1 is essential for innate host defense against bacterial sepsis - PubMed
5 hours ago
- #phagocytosis
- #PACC1
- #sepsis
- Proton-activated chloride channel 1 (PACC1) is enriched in mononuclear phagocytes and regulated by inflammatory stimuli.
- PACC1 knockout mice show impaired acidifying phagolysosome formation in myeloid cells, affecting bacterial clearance.
- PACC1 deficiency leads to increased bacterial burden, inflammation, and lethality in E. coli sepsis models.
- PACC1 is not essential for survival in LPS-induced endotoxemia, indicating its role is phagocytosis-dependent.
- Myeloid-specific deletion of PACC1 impairs sepsis survival but does not affect endotoxemia responses.