Multi-omics and machine learning reveal a critical mediator of PRKCA in quercetin-mediated protection against Sarcopenia - PubMed
6 hours ago
- #quercetin
- #sarcopenia
- #PRKCA
- Quercetin intake is inversely and dose-dependently associated with sarcopenia risk, as identified through machine learning analysis of NHANES data.
- Mendelian randomization and multi-omics approaches link quercetin to the PRKCA gene, which mediates its protective effects against sarcopenia.
- Quercetin promotes myoblast differentiation by upregulating PRKCA and enhancing ERK1/2 phosphorylation, effects blocked by PRKCA inhibition.
- The study integrates epidemiological data, computational models, and experimental validation to elucidate quercetin's role in muscle health via PRKCA-ERK signaling.