Impact of vitamin D deficiency on defective endometrial decidualization and the repressive role of vitamin D receptor (VDR) in the epigenomic network - PubMed
5 hours ago
- #Vitamin D
- #Epigenomics
- #Decidualization
- Vitamin D deficiency impairs hormonally induced decidualization in mice.
- VDR levels decrease during in vitro decidualization in human endometrial stromal cells (T-HESC).
- siRNA knockdown of VDR enhances decidualization, while VDR overexpression inhibits it.
- VDR acts as a chromatin regulator, restricting accessibility and repressing transcription in specific genomic regions.
- Transcriptomic analyses show VDR broadly modulates gene expression, primarily through ligand-mediated effects.
- Findings suggest VDR is a key regulator of transcriptional and chromatin landscapes in endometrial stromal cells.
- Potential for targeting vitamin D pathways to treat uterine disorders linked to impaired decidualization and fertility issues.