TLR9/MyD88/NF-κB signaling mediates mental stress-induced exacerbation of psoriasis through immune dysregulation in a mouse model - PubMed
4 days ago
- #Immune Dysregulation
- #Psoriasis
- #Mental Stress
- TLR9/MyD88/NF-κB signaling pathway is upregulated in psoriasis patients and mental stress-treated psoriatic mice.
- Mental stress activates the TLR9/MyD88/NF-κB pathway, increasing inflammatory factors and altering immune cell ratios (Th17/Treg and Treg/CD4+T).
- Interventions like antipsychotic sertraline, pathway inhibitors, and lentiviral transfection improved psoriasis severity by reducing inflammation.
- The study highlights the role of mental stress in exacerbating psoriasis through immune dysregulation.