Associations of Life's Essential 8 With Mortality Among Individuals With Diabetes and/or Hypertension: Statistical Mediation by Inflammation and Biological Aging - PubMed
4 hours ago
- #mortality mediation
- #chronic disease
- #cardiovascular health
- Higher Life's Essential 8 (LE8) scores are significantly associated with reduced all-cause and heart disease mortality in individuals with diabetes, hypertension, or both.
- The association between LE8 scores and mortality was stronger among younger individuals (under 60) and those with higher socioeconomic status.
- Inflammation markers (neutrophil-to-lymphocyte ratio [NLR] and pan-immune-inflammation value [PIV]) and phenotypic age acceleration (PhenoAgeAccel) statistically mediate the LE8-mortality relationship.
- Mediation effects varied by disease group: NLR and PIV accounted for larger proportions in diabetes, PhenoAgeAccel for hypertension, and both contributed in individuals with both conditions.
- The study suggests inflammation and biological aging as potential statistical mediators, highlighting pathways for future research and therapeutic targets.
- Based on NHANES data (2005-2018), the analysis included 4939 individuals with diabetes, 13,298 with hypertension, and 3303 with both conditions.