Neural Stem Cell-Derived Exosomes-Transmitted miR-31-5p Promote Functional Recovery of Spinal Cord Injury by Shifting Astrocytes A1/A2 Polarization - PubMed
18 hours ago
- #spinal-cord-injury
- #astrocytes
- #exosomes
- Neural stem cell-derived exosomes enhance motor recovery after spinal cord injury by shifting astrocytes from harmful A1 to protective A2 phenotypes.
- miR-31-5p is the most enriched miRNA in these exosomes and targets interleukin-34 (Il34), downregulating the Il34/Stat3 signaling pathway in astrocytes.
- Rescue experiments confirm that miR-31-5p-mediated inhibition of Il34/Stat3 promotes astrocyte phenotypic change and neurorepair, suggesting therapeutic potential for SCI.