Human microglial transitions at the Aβ-tau inflection point associate with divergent pathways to dementia and resilience - PubMed

4 hours ago

Alzheimer's disease progression involves a shift from Aβ-associated inflammation to tau-associated cellular programs.
Microglial states transition from early inflammatory to late antigen-presenting phenotypes (early and late PIG programs).
Resilient octogenarians without dementia lack late PIG activation, while resilient centenarians show late PIG activation uncoupled from tau accumulation.
Microglial state transitions at the Aβ-tau interface are identified as key resilience mechanisms with therapeutic potential.

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