Mapping circulating microRNA signatures in type 1 diabetic microvascular disease: A systematic review and Bayesian multilevel meta-analysis with bioinformatic integration of molecular dysregulation -
5 hours ago
- #microRNA
- #Type 1 diabetes
- #Meta-analysis
- Systematic review and Bayesian meta-analysis evaluated microRNAs (miRNAs) linked to microvascular complications in type 1 diabetes (T1D).
- Identified miR-29a-3p and miR-204-5p as consistently downregulated in diabetic nephropathy (DN).
- No universal circulating miRNA signature was found across T1D microvascular complications due to heterogeneity.
- Enrichment analyses revealed dysregulated pathways like autophagy, Wnt signaling, fibrosis, and apoptosis.
- Study provides a framework for future research on miRNA biomarkers in T1D microangiopathy.