Reduced nuclear TDP-43 and cytoplasmic DLK1 as markers of motor neuron degeneration in amyotrophic lateral sclerosis - PubMed
5 hours ago
- #TDP-43
- #ALS
- #DLK1
- Study focuses on motor neuron (MN) degeneration in ALS, highlighting differences in TDP-43 pathology between upper and lower MNs.
- Findings show severe MN loss in both upper and lower MN areas, with TDP-43-positive inclusions rare in upper MNs but abundant in lower MNs.
- In upper MN areas, TDP-43 density did not correlate with MN residual rate, whereas in lower MNs, it was associated with cell residual rate.
- Higher numbers of MNs lacking nuclear TDP-43 and cytoplasmic DLK1 were observed in ALS patients compared to controls.
- Morphological changes in TDP-43 and DLK1 may be linked to motor neuron vulnerability and ALS development.