Hybrid macrophage-mitochondria extracellular vesicles for mitochondrial ROS regulation in diabetic wounds - PubMed
5 hours ago
- #extracellular vesicles
- #mitochondrial ROS
- #diabetic wounds
- Hybrid macrophage-mitochondria extracellular vesicles (C@AH-EV) are developed for mitochondrial ROS regulation in diabetic wounds.
- C@AH-EV integrates biomimetic dual-targeting membranes with an mtROS activatable prodrug for selective intracellular delivery.
- The payload includes a ROS-sensitive antioxidant prodrug with lipid tails for enhanced drug loading efficiency.
- mtROS-triggered cleavage releases potent antioxidants locally within mitochondria to restore redox balance.
- In vitro and in vivo studies show C@AH-EVs reprogram macrophages from inflammatory to anti-inflammatory phenotypes.
- This approach attenuates inflammation and accelerates diabetic wound repair, offering a promising treatment for chronic inflammatory conditions.