Targeting of kinases to treat neurodegenerative diseases - PubMed
5 hours ago
- #drug development
- #kinase inhibitors
- #neurodegeneration
- Protein kinases are important regulators in cellular processes like endolysosomal trafficking, neuroinflammation, and mitochondrial homeostasis, and their dysregulation is linked to neurodegenerative diseases.
- Key kinases implicated in neurodegeneration include p38 MAPK, BTK, c-Abl/ABL1, CDK5, GSK3, JNK, LRRK2, and PINK1, which are potential drug targets for diseases such as Alzheimer's, Parkinson's, and multiple sclerosis.
- The review discusses the roles of these kinases in disease pathophysiology, current therapeutic strategies, and structural insights for developing more selective kinase inhibitors.
- Challenges in targeting kinases for neurodegenerative diseases include achieving selectivity and effective drug delivery to the brain, despite advancements in kinase biology and novel therapeutic approaches.
- Continued research is needed to identify new kinase targets and translate scientific breakthroughs into effective, disease-modifying therapies for patients with neurodegenerative conditions.