NANP targeting radiosensitizes glioblastoma through TNFR1 sialylation-driven mesenchymal shift - PubMed
5 hours ago
- #glioblastoma
- #TNFR1
- #radiosensitization
- Glioblastoma (GBM) patients show poor survival due to resistance to ionizing radiation therapy (RT).
- A genome-wide CRISPR screen identifies N-acylneuraminate-9-phosphatase (NANP) as a top-ranked radiosensitizing target linked to patient outcomes.
- NANP-deficient cells exhibit increased DNA damage, G2/M arrest, apoptosis, and impaired DNA repair post-radiation.
- NANP influences NF-κB signaling and the mesenchymal state by modulating TNFR1 sialylation and internalization.
- Intracranial xenograft experiments confirm NANP's role in vivo, suggesting a pathway for developing GBM RT sensitizers.