Neuroprotective Effects of RNS60 in TDP-43 Pathology-Associated Amyotrophic Lateral Sclerosis - PubMed
4 hours ago
- #Neuroprotection
- #Amyotrophic Lateral Sclerosis
- #Mitochondrial Function
- RNS60 treatment in a TDP-43 mouse model of ALS reduced defective mitochondria in upper motor neurons and spinal motor neurons.
- It increased mitochondrial membrane polarization, reduced astrogliosis and microgliosis in motor cortex and spinal cord, and protected upper motor neurons.
- RNS60 enhanced the proportion of intact neuromuscular junctions in leg and diaphragm muscles, suggesting it promotes motor neuron health by protecting mitochondrial structure and function.