Dachaihu decoction alleviates septic liver injury by modulating the intestinal barrier dysfunction and suppressing the NF-κB/NLRP3/Caspase-1 signaling pathway - PubMed
5 hours ago
- #Gut-Liver Axis
- #Sepsis
- #Traditional Chinese Medicine
- Dachaihu decoction (DCHD) alleviates septic liver injury in a mouse model by improving liver function, reducing inflammation, and decreasing oxidative stress and hepatocyte apoptosis.
- DCHD enhances intestinal barrier integrity, reducing permeability and limiting translocation of gut-derived LPS to the liver, while also remodeling the gut microbiota to favor beneficial bacteria.
- The protective mechanism involves suppression of the NF-κB/NLRP3/Caspase-1 signaling pathway, as validated through network pharmacology, transcriptomics, and functional experiments including TLR4 and NLRP3 inhibition.