Age-related B cell dysfunction at the aging-cancer nexus: from shared manifestations to therapeutic potential - PubMed
7 hours ago
- #Cancer
- #B cell dysfunction
- #Aging
- Aging and cancer are linked through complex interactions, with immune remodeling as a key convergence point.
- B cells undergo significant functional and phenotypic changes during aging and tumorigenesis, termed age-related B cell dysfunction.
- Age-related B cell dysfunction includes impaired germinal center response, reduced B cell diversity, pro-inflammatory phenotypes, and increased autoreactivity.
- Shared biological hallmarks between aging and cancer include genomic instability, epigenetic reprogramming, chronic inflammation, and dysbiosis.
- Maladaptive B cell programs influence tumor evolution, therapy responses, and treatment-related toxicities.
- Emerging strategies target age-related dysfunctional B cells in cancer, leveraging insights from aging biology and tumor immunology.