Serpina3c protects against metabolic dysfunction-associated steatotic liver disease in offspring induced by prenatal prednisone exposure - PubMed
2 days ago
- #Serpina3c
- #Prenatal exposure
- #MASLD
- Prenatal prednisone exposure (PPE) increases susceptibility to metabolic dysfunction-associated steatotic liver disease (MASLD) in offspring.
- PPE reduces hepatic glucose uptake and fatty acid oxidation, leading to more severe MASLD, especially in male offspring.
- Hepatic Serpina3c expression is consistently reduced in PPE offspring, increasing chymase-Ang II production and activating AT1R, contributing to MASLD.
- Low Serpina3c expression is linked to reduced H3K27ac levels in its promoter region due to GR-HDAC3 signaling activation by prednisolone.
- Postnatal high expression of Serpina3c reverses chymase-Ang II-AT1R pathway activation and improves metabolic dysfunction in PPE offspring.