Aging-Driven Inter-Organ Crosstalk in Postmenopausal Osteoporosis: From Immunometabolic Drift to Multisystem Frailty - PubMed
5 hours ago
- #immunometabolism
- #osteoporosis
- #frailty
- Postmenopausal osteoporosis (PMOP) is recognized as an aging-associated, multisystem vulnerability state.
- Estrogen withdrawal amplifies immune and metabolic drift across various tissues including bone marrow, muscle, and adipose tissue.
- Key control nodes like RANKL-RANK-OPG imbalance and Th17/Treg disequilibrium contribute to persistent osteoclastogenic tone.
- Microbiota-derived metabolites and barrier dysfunction influence osteoimmunity.
- Exercise-responsive myokines and metabolites can counteract metabolic and immune drift.
- Extracellular vesicles play a role in propagating senescence and inflammation or supporting repair.
- A proposed 'network reset' roadmap integrates antifracture therapy with functional restoration and falls prevention.
- PMOP management should shift from bone-only correction to whole-body resilience.