sRNA centered signaling activates nitrate respiration and enhances Cronobacter sakazakii virulence in host environments - PubMed
12 hours ago
- #Cronobacter sakazakii
- #nitrate respiration
- #virulence
- Cronobacter sakazakii is a neonatal pathogen linked to powdered infant formula.
- A novel sRNA, CsrN, is central to a signal transduction pathway enhancing C. sakazakii virulence.
- CsrN is induced under anaerobic conditions via the ArcAB two-component system.
- CsrN enhances the narGHJI operon, promoting nitrate respiration and bacterial survival in host environments.
- Nitrate respiration aids colonization in the gastrointestinal tract and survival within macrophages.
- Tungstate, a nitrate respiration inhibitor, reduces C. sakazakii virulence in animal models.
- The study suggests nitrate respiration as a potential therapeutic target for C. sakazakii infections.