Lactylation of β-catenin promotes non-small cell lung cancer by inhibiting ferroptosis through TCF4-mediated GPX4 transcription - PubMed
3 days ago
- #Ferroptosis
- #Lactylation
- #NSCLC
- β-catenin lactylation at lysine 193 (K193) promotes non-small cell lung cancer progression.
- Lactylation enhances β-catenin stability and suppresses ferroptosis by increasing GPX4 transcription.
- Mechanism involves β-catenin-TCF4 complex binding to the GPX4 promoter, regulated by lactate levels.
- Inhibition of lactylation reduces tumor growth in vivo and cell proliferation in vitro.
- Clinical samples show elevated lactate and lactylation in NSCLC compared to controls.