The novel adipokine Placin regulates glucose homeostasis via insulin secretion and IGF1 receptor signaling - PubMed
3 days ago
- #adipokine
- #glucose homeostasis
- #diabetes therapy
- PLAC9, now proposed to be renamed Placin, is identified as a novel adipokine enriched in adipose tissue's stromal vascular fraction.
- Circulating Placin levels correlate with metabolic dysregulation markers in humans and mice, and it regulates systemic metabolism via insulin secretion and IGF1 receptor signaling.
- In mouse models, Placin knockdown worsened metabolic impairments, while overexpression or recombinant protein administration alleviated hyperglycemia in insulin-resistant and insulin-deficient conditions.
- Mechanistically, Placin enhances calcium-dependent insulin secretion in pancreatic beta cells, promotes glucose uptake in liver and muscle, and upregulates hepatic Ghr and Igf1 levels.
- Placin is highlighted as a promising therapeutic target with translational potential for managing both type 2 and type 1 diabetes.