Sgk1 upregulation in hippocampus-projecting amygdala neurons underlies the delayed onset of PTSD-like avoidance behavior - PubMed
21 hours ago
- #SGK1
- #Amygdala Circuits
- #PTSD
- Stress exposure leads to enhanced glucocorticoid receptor (GR) signaling in hippocampus-projecting amygdala neurons.
- SGK1 is a key downstream mediator of GR signaling, driving hyperactivation of BLA→vHPC projection neurons.
- Upregulation of SGK1 in these specific neurons correlates with delayed onset of PTSD-like avoidance behavior.
- Bidirectional manipulation of SGK1 expression can regulate neuronal activity and susceptibility to stress-induced avoidance.
- Projection-specific activation of amygdala neurons is critical for PTSD-like avoidance, distinguishing hippocampus-targeting from nucleus accumbens-targeting neurons.