Low dose of lithium reverses Alzheimer's symptoms in mice
18 days ago
- #Lithium
- #Cognitive decline
- #Alzheimer’s disease
- People with Alzheimer’s disease have lower levels of lithium in their brains.
- Lithium supplementation in mice reversed cognitive decline and reduced amyloid plaques.
- Previous studies link lithium to reduced Alzheimer’s risk, but confounding factors may exist.
- Post-mortem analysis showed 36% lower lithium in Alzheimer’s patients' prefrontal cortex.
- Amyloid plaques in Alzheimer’s brains contained three times more lithium than plaque-free areas.
- Lithium-deficient mice showed worse memory and more amyloid plaques.
- Lithium orotate was effective in reducing plaques and improving memory in mice.
- High-dose lithium treatments for psychiatric conditions can cause toxicity, but low doses may be safer.
- Clinical trials are needed to assess low-dose lithium orotate in humans.