OGT Ameliorates Diabetes-Associated Cognitive Decline via Modulation of DRP1 Function and Mitochondrial Homeostasis - PubMed
5 hours ago
- #OGT
- #Cognitive Decline
- #Mitochondrial Homeostasis
- OGT deficiency disrupts mitochondrial homeostasis, leading to cognitive impairment in diabetic mice.
- OGT interacts with DRP1; its deficiency promotes mitochondrial fission and impairs function by modulating DRP1.
- Hippocampus-specific OGT overexpression improves diabetes-associated cognitive decline (DACD) in mice.
- Semaglutide alleviates DACD by acting through the OGT/DRP1 pathway.
- Semaglutide may be a potential therapeutic for DACD due to its OGT protective effect.