The stem of Schisandra chinensis and Schisandrin B alleviated DNCB-induced atopic dermatitis in mice by inhibiting the NF-κB pathway - PubMed
8 days ago
- #NF-κB pathway
- #Atopic Dermatitis
- #Schisandra chinensis
- Schisandra chinensis stem extract (SCSE) and Schisandrin B (Sch B) alleviate atopic dermatitis (AD) in mice.
- The study identified Sch B as the core active component through activity-guided assays.
- SCSE and Sch B improved skin barrier function by reducing transepidermal water loss and upregulating barrier proteins.
- They alleviated pruritus by suppressing TRPV1 and reduced allergic-inflammatory responses by lowering IgE levels and inhibiting mast cell mediators.
- The therapeutic effects are mediated through the inhibition of the NF-κB pathway.
- SCSE and Sch B show promise as novel therapeutic candidates for AD by targeting multiple disease mechanisms.