RNA Modifications in Tumor Microenvironment: A New Dimension for Cancer Treatment - PubMed
4 hours ago
- #Cancer therapy
- #Tumor microenvironment
- #RNA modifications
- RNA modifications are key regulators of gene expression involved in cancer initiation and progression.
- In the tumor microenvironment (TME), these modifications affect tumor growth, immune evasion, and therapy resistance.
- They regulate RNA metabolism, genome integrity, and stromal pathways like immune responses and matrix remodeling.
- RNA modifications facilitate communication between tumor cells and stromal or immune cells in the TME.
- This review covers mechanisms of major RNA modifications (e.g., adenosine, guanosine, pseudouridine).
- Therapeutic strategies targeting RNA-modifying enzymes show promise for improving cancer treatment outcomes.