Mutant p53 epigenetically rewires CXCL10 to promote CD8⁺ T-cell infiltration and enhance the anti-PD-1 response in advanced prostate cancer - PubMed
4 hours ago
- #Prostate Cancer
- #Mutant p53
- #Immunotherapy
- Mutant p53 epigenetically rewires CXCL10 to promote CD8+ T-cell infiltration in advanced prostate cancer.
- Enhances the anti-PD-1 response, potentially improving immunotherapy outcomes.
- Study involves single-cell RNA sequencing to understand the CXCL10-CXCR3 axis role.
- Research conducted with approval from the Animal Ethics Committee of Anhui Medical University.
- No human participants were involved; all procedures were animal-based.
- Authors declare no competing interests.
- Supported by grants from the National Natural Science Foundation of China and Anhui Province.