Combined radiation and Listeria immunotherapy induces cytotoxic immunity that correlates with improved outcome in dogs with osteosarcoma - PubMed
5 hours ago
- #Immunotherapy
- #Combination Therapy
- #Osteosarcoma
- Combined radiation and Listeria immunotherapy (Lm-LLO-HER2) shows synergistic anti-tumor effects by inducing immunogenic cell death and modulating the tumor microenvironment.
- In a pilot study on dogs with osteosarcoma, the combination treatment delayed primary tumor progression and prolonged overall survival in 5 out of 15 dogs, with good tolerability.
- Transcriptomic analysis revealed that baseline immune status and response to immunotherapy distinguish long-term from short-term survivors, with downregulation of genes related to Hedgehog signaling, senescence, DNA repair, and cell cycle in long-term survivors.
- The findings support further exploration of this combination therapy for osteosarcoma and suggest baseline immune status may predict treatment response, with relevance to pediatric osteosarcoma clinical trials.