A mitochondria-targeted nanoantioxidant restores alveolar bone homeostasis in periodontitis by quenching ROS and suppressing the cGAS-STING pathway - PubMed
4 hours ago
- #Periodontitis
- #Nanoantioxidant
- #Mitochondria-targeted
- Mitochondria-targeted nanoantioxidant (TC/pSeSe) developed to treat periodontitis.
- TC/pSeSe restores alveolar bone homeostasis by quenching ROS and suppressing cGAS-STING pathway.
- The nanocomposite has a ROS-responsive diselenide-containing core (pSeSe) and a mitochondrial-targeting coating (TC).
- TC/pSeSe restores mitochondrial redox homeostasis and attenuates mtDNA-cGAS-STING inflammatory signaling.
- It mitigates ferroptosis in a GPX4-dependent manner and restores osteogenic potential in stem cells.
- Exhibits antibacterial activity against periodontal pathogens through selenium and cationic TC functionalities.
- In vivo, TC/pSeSe promotes alveolar bone regeneration and reduces periodontal inflammation.
- Study proposes a mitochondria-centered redox modulation strategy for periodontitis treatment.