RFC4 drives temozolomide resistance in glioblastoma by activating STK38-BECN1-dependent autophagy - PubMed
5 hours ago
- #chemoresistance
- #glioblastoma
- #autophagy
- RFC4 is linked to temozolomide (TMZ) resistance in glioblastoma (GBM).
- TMZ-induced chromatin changes allow YY1 to upregulate RFC4 expression.
- RFC4 stabilizes STK38, which is crucial for autophagosome formation.
- The RFC4-STK38 interaction recruits BECN1, activating autophagy.
- Phosphorylation of STK38 at T444 stabilizes the autophagy complex.
- RFC4 overexpression in vivo leads to TMZ resistance, reversible by autophagy inhibition.
- The RFC4-STK38-BECN1 axis is a potential target for GBM precision therapy.