Molecular Mechanisms and Nutritional Modulation in Sarcopenia: A Narrative Review - PubMed
5 hours ago
- #Nutritional Modulation
- #Molecular Mechanisms
- #Sarcopenia
- Sarcopenia is a progressive muscle disorder leading to decreased strength, function, and increased risks of frailty, falls, and mortality.
- Molecular mechanisms include anabolic resistance, mitochondrial dysfunction, neuromuscular instability, chronic inflammation, impaired regeneration, and disrupted proteostasis.
- Nutritional interventions like high-quality protein, leucine metabolites, and vitamin D help preserve lean mass but often fail to restore function alone.
- Exercise is the cornerstone therapy but may be limited in patients with multimorbidity or reduced mobility.
- There is a need for stratified, mechanism-based therapies due to sarcopenia's biological heterogeneity.
- Omics technologies (transcriptomic, proteomic, metabolic profiling) offer potential to define molecular endotypes for precision management strategies.