Biomimetic Ru-Mn Nanozyme with Cascade Catalytic Activity Attenuates Secondary Brain Injury in Intracerebral Hemorrhage - PubMed
5 hours ago
- #intracerebral hemorrhage
- #nanozyme
- #neuroinflammation
- Development of a ruthenium (Ru)-manganese (Mn) composite nanozyme (Ru@Mn-ZIF) for treating intracerebral hemorrhage (ICH).
- The nanozyme exhibits cascade catalytic activity to efficiently clear reactive oxygen species (ROS).
- In vitro tests showed reduced microglia activation and neuronal oxidative damage compared to Mn-ZIF alone.
- In vivo studies demonstrated decreased hematoma volume, preserved blood-brain barrier integrity, and improved neurological recovery in ICH models.
- Both intranasal and intravenous administration of Ru@Mn-ZIF nanozyme were effective.
- Biosafety evaluations confirmed no pathological or biochemical abnormalities post-treatment.
- Potential therapeutic strategy for mitigating secondary brain injury post-ICH.