ACADM-mediated fatty acid β-oxidation pathway in atherosclerosis and abdominal aortic aneurysm - PubMed
3 hours ago
- #lipid metabolism
- #multi-omics analysis
- #cardiovascular disease
- The study investigates lipid metabolism differences between atherosclerosis (AS) and abdominal aortic aneurysm (AAA), using lipidomic, transcriptomic, and metabolomic analyses.
- Neutral lipids like triglycerides and cholesterol esters are predominant in AS, while phosphoglycerides are enriched in AAA, influencing disease risk differently.
- Fatty acid metabolism, particularly the ACADM-mediated β-oxidation pathway, is a key driver of lipid differences between AS and AAA.
- Restoration of the ACADM-mediated pathway inhibits AS by reducing lipotoxic metabolites and preserving mitochondrial homeostasis, but has minimal impact on AAA.
- Use of a lipid droplet autophagy-tethering compound (LD·ATTEC) alleviates AS progression and improves fatty acid oxidation without significant effects on AAA.
- Machine learning models based on lipidomic features enable accurate differentiation between AS and AAA for differential diagnosis and targeted treatments.