Body Roundness Index and All-Cause Mortality in Metabolic Dysfunction-Associated Steatotic Liver Disease: A Dual-Cohort Study - PubMed
5 hours ago
- #MASLD
- #All-Cause Mortality
- #Body Roundness Index
- The study investigates the association between Body Roundness Index (BRI) and all-cause mortality in Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) using two cohorts: NHANES (US) and CHARLS (China).
- In the NHANES cohort (US), BRI showed a significant linear association with higher all-cause mortality (HR 1.18 per SD, p=0.006), while in the CHARLS cohort (China), no significant association was found, likely due to insufficient statistical power.
- Substantial heterogeneity (I²=80.7%) was observed between cohorts, attributed to differences in age, obesity phenotypes, mortality ascertainment, and potential population-specific factors.
- The Triglyceride-Glucose (TyG) index explained 33.8% of the BRI-mortality association attenuation in NHANES, suggesting a mediating role of metabolic dysfunction.
- Findings emphasize the need for population-specific validation of BRI thresholds, cautioning against extrapolating Western-derived metrics to Asian populations without further powered studies.