Five tenets for advancing evidence-based precision medicine - PubMed
5 hours ago
- #health outcomes
- #clinical translation
- #precision medicine
- Precision medicine aims to improve risk prediction, therapeutic response, and prognosis for complex diseases using individual-level characteristics.
- Despite advancements, translating precision medicine research into clinical practice, especially beyond oncology, has seen limited success.
- Five key tenets are proposed to enhance clinical translation: addressing heterogeneity in risk, response, and prognosis; ensuring signal robustness; structured statistical benchmarking; precision trial designs; and evaluating risks and benefits to individuals and society.
- The goal is to achieve clinically meaningful, reproducible, scalable, and equitable health outcomes through precision medicine.
- The authors disclose various competing interests, including consulting fees, research grants, and affiliations with pharmaceutical companies and health organizations.