The NTR/prodrug revolution: Tools for controlling cell loss and regeneration - PubMed
3 hours ago
- #Cell Ablation
- #Regeneration
- #Disease Modeling
- Reviews the NTR/prodrug system as a chemogenetic tool for precise cell ablation.
- Highlights its application across model organisms, especially zebrafish, for disease modeling and regeneration studies.
- Discusses advancements like NTR2.0 and potent prodrugs (e.g., RNZ) enabling chronic ablation.
- Provides considerations for transgenic design, expression calibration, and controls for reproducibility.