Natural panax notoginseng-derived nanovesicles trigger multiple cell death mechanisms and reprogram chemokine signaling to impede oral squamous cell carcinoma progression - PubMed
5 days ago
- #Nanovesicles
- #Oral squamous cell carcinoma
- #Panax notoginseng
- Oral squamous cell carcinoma (OSCC) is a highly aggressive malignancy with limited effective treatments.
- Panax notoginseng-derived nanovesicles (PnNVs) were identified as potent inhibitors of OSCC, showing favorable safety and tumor-homing ability.
- PnNVs suppressed primary tumor growth and lymphatic metastasis in vivo.
- Mechanistically, PnNVs disrupted redox homeostasis by inhibiting the p38-MAPK/NRF2 pathway, inducing ferroptosis, autophagy, and PANoptosis.
- PnNVs also impaired cancer cell migration by modulating chemokine-associated signaling pathways.
- Multi-omic analyses revealed synergistic effects of RNA cargos and metabolite components in PnNVs' anticancer efficacy.
- PnNVs represent a natural, multifunctional therapeutic candidate with dual anti-proliferative and anti-metastatic activity for OSCC treatment.