Antigen-Specific mRNA-LNP Therapy with mTOR Inhibition Promotes Treg Cells and Limits Allergy - PubMed
5 hours ago
- #Allergy immunotherapy
- #mTOR inhibition
- #mRNA-LNP therapy
- Antigen-specific mRNA-LNP therapy combined with mTOR inhibition promotes Treg cells and suppresses allergic responses.
- Combining an allergen-encoded mRNA-LNP vaccine with an mTOR inhibitor enhances regulatory T-cell responses in a mouse asthma model.
- The combination therapy shifts immunity from Th1 and cytotoxic CD8+ T cells toward Treg cells, reducing airway inflammation and cytotoxicity.
- This strategy reduces eosinophil activation, airway hyperresponsiveness, and mucus production while preserving anti-allergic effects.
- The findings suggest a potential therapeutic approach for enhancing immune tolerance in allergic and inflammatory diseases.