Identification of a novel monoclonal antibody derived from the lumpy skin disease virus ORF123 that confers cross-binding and cross-neutralizing activity against Capripoxvirus members - PubMed
5 hours ago
- #monoclonal antibody
- #epitope
- #Capripoxvirus
- Identification of a novel monoclonal antibody (mAb) from lumpy skin disease virus (LSDV) ORF123 with cross-binding and neutralizing activity against Capripoxvirus members.
- The mAb targets a conserved epitope (85PYFLKN90) in LSDV and goat poxvirus (GTPV), with slight variations in critical amino acids.
- Sheep poxvirus (SPPV) recognition by the mAb is affected by a natural point mutation (P to Q at amino acid 85).
- Demonstrated cross-neutralizing activity against LSDV, GTPV, and extracellular SPPV replication.
- Findings support the development of universal vaccines and therapeutic antibodies for Capripoxviruses.
- Research conducted under ethical guidelines approved by Lanzhou Veterinary Research Institute (LVRI) and Chinese Academy of Agricultural Sciences (CAAS).