Development of nanoemulsion formulation loaded with Enteromorpha intestinalis extract: Characterization and evaluation for topical use - PubMed
4 days ago
- #Enteromorpha intestinalis
- #topical application
- #nanoemulsion
- Development of a nanoemulsion formulation loaded with Enteromorpha intestinalis (EI) extract for topical use.
- Formulation components include olive oil, Tween-80 (surfactant), and PEG-400 (co-surfactant) with a Smix ratio of 1:1.
- Optimal formulation (F6) showed droplet size of 183.27 ± 20.04 nm, PDI of 0.6, and viscosity of 290 ± 5.77 m-Pa.S.
- The nanoemulsion exhibited good skin compatibility, slightly acidic pH, and concentration-dependent antioxidant activity.
- Nanoemulsion had a lower IC50 value (163.19 μg/mL) compared to the seaweed extract alone, indicating greater efficacy.
- Significant anti-inflammatory activity (8-31% inhibition of paw volume) compared to control, with diclofenac sodium at 41%.
- Stable, effective, and non-irritating formulation, suitable for potential topical applications.
- First study to incorporate E. intestinalis extract into a nanoemulsion, paving the way for in vivo studies.